Chemistry 4850 & 4850L - Undergraduate Research

Chemistry 4850 - course description

Research planning, design and execution including literature survey techniques, proposal writing and critical scientific analysis. The student will give an oral presentation of a research proposal for CHEM 4850L, or on another topic as approved by the instructor. Required of BS and BA chemistry majors. One hour lecture. 1 SH

Prereq.: CHEM 2604 or 3719 and approval of department chair.

Chemistry 4850L - course description

Research participation under the direction of a faculty member. The student will prepare an acceptable written report on the completed project. May be repeated to a maximum of 5 s.h. 2-3 SH

Prereq. or Concurrent: CHEM 4850 and approval of department chair.

Chemistry 4850L in the Norris Lab

This is a chance to get into a chemistry lab and have a go at original research. None of that "cook-book" stuff from chemistry classes, this is science that has never been done before; a real opportunity to see how a lab works and to get involved with an ongoing research effort. It is absolutely invaluable experience if you want to go to graduate school in chemistry and will make you highly competitive if you want to enter the job market as a BS scientist. You will gain plenty of experience in many of the following:

Reaction setup including inert atmosphere work, analysis by TLC, reaction workup, product isolation, and purification by techniques such as flash column and crystallization

Analysis of products by 1H and 13C NMR by learning to use the department's 400 MHz NMR spectrometers, as well as by IR and MS techniques

Molecular modeling of compounds using packages such as PC Spartan and Alchemy

X-Ray crystallography on suitable samples using the department's diffractometers under the guidance of Dr. Matt Zeller or Dr. Tim Wagner

Undergraduate students are involved in various projects aimed at glycomimetic synthesis and reaction development, including our attempts to produce new antibiotics against Staphylococcus aureus. Over the summer of 2007 students discovered an interesting SN2 conversion (below) that was featured in a recent YSUpdate story (link). If you have taken Chemistry 3719/3720 and are interested in research, drop by 6014 Ward Beecher to see what we have to offer.

Recent publications from the Norris Group featuring undergraduate coauthors:

"Crystal structure of 1-(2,3:5,6-di-O-isopropylidene-beta-D-mannofuranosyl)-1H-[1,2,3]-triazol-4,5-dicarboxylic acid diethyl ester," H. Seibel, P.L. Miner, P. Norris, and T.R. Wagner, J. Chem. Cryst., 2007, 37, 157-163.

"Application of Bis(diphenylphosphino)ethane in Staudinger-type N-Glycosyl Amide Synthesis," D.P. Temelkoff, C.R. Smith, D.A. Kibler, S. McKee, S. Duncan, M. Zeller, M. Hunsen, and P. Norris, Carbohydr. Res. 2006, 341, 1645-1656.

"Cu(I)-Catalyzed formation of D-mannofuranosyl 1,4-disubstituted 1,2,3-triazole carbohybrids," P.L. Miner, T.R. Wagner, and P. Norris, Heterocycles, 2005, 65, 1035-1049.

"Rapid access to glucopyranosyl-1,2,3-triazoles via Cu(I)-catalyzed reactions in water," D.P. Temelkoff, N.D. Artis, and P. Norris, Heterocycles, 2004, 63, 2719-2725.